Yeast pheromone response model

From Yeast Pheromone Model

Contents

Receptor/G protein interactionsSte2RGS(Sst2)/Galpha(Gpa1)/Receptor(Ste2) interactionsSst2Gpa1Ste4Ste18Ste20Ste7Ptp3Msg5Ptp2Ste11/Ste50 interactionsSte11Ste50Fus3Fus3Kss1Kss1Ste5Ste5Dig1/Dig2/Ste12 interactionsDig1Dig2Ste12Ste12 mediated protein synthesisPheromone/Receptor interactionsPheromoneReceptor/G protein interactionsSte2RGS(Sst2)/Galpha(Gpa1)/Receptor(Ste2) interactionsSst2Gpa1Ste18Ste4/Ste5 interactions and Ste5 dimerization/oligomerizationSte4/Ste20 interactionSte4Ste20Ste5/MAPK cascade interactionsSte11/Ste50 interactionsSte50Ste11Ste7Fus3MAPK phosphorylation cascadePtp3Msg5Ste5Fus3Kss1Fus3Kss1Ptp2Dig1/Dig2/Ste12 phosphorylationDig1/Dig2/Ste12 interactionsDig1Dig2Ste12Ste12 mediated protein synthesis

Reactions

Receptor/G-Protein

Pheromone/Receptor/G protein interactions

G protein nucleotide hydrolysis/exchange

RGS(Sst2)/Galpha(Gpa1)/Receptor(Ste2) interactions

Gβ(Ste4)/Gγ(Ste18) interaction

Fus3/Gpa1/Ste4 interactions

Synthesis/Degradation

Receptor(Ste2) synthesis/endocytosis/degradation

RGS(Sst2) synthesis/degradation

Gα(Gpa1) synthesis/degradation

MAPK Cascade

Ste4:Ste18/Ste5 interactions and Ste5 dimerization/oligomerization

Ste4:Ste18/Ste20 interaction

Ste5/MAPK cascade interactions

MAPK phosphorylation cascade

MAPK/phosphatase interactions

Ste7/MAPK interactions

Ste11/Ste50 interactions

Synthesis/Degradation

Ste11 synthesis/degradation

Ste7 synthesis/degradation

Gene Expression

Dig1/Dig2/Ste12/Tec1 interactions

Dig1/Dig2/Ste12 phosphorylation

Ste12 mediated protein synthesis

Synthesis/Degradation

Tec1 synthesis/degradation
Ste12 synthesis/degradation

Other

Far1/MAPK interactions

Non-specific dephosphorylation

Protein dilution/synthesis due to cell growth

Cell cycle regulation of pheromone response

Pheromone-dependent cell cycle arrest

Parameter Constraint Assumption Pages

MAPK/target interaction properties
Gpa1/Ste4 binding and nucleotide hydrolysis/exchange rate constant constraints
Ste2/Gpa1/Ste4:Ste18 binding rate constant constraints
Ste5 dimerization and Ste4 binding rate constant constraints
Dig1/Dig2/Ste12/MAPK binding rate constant constraints

Elemental Species

Cell
Dig1
Dig2
Far1
Fus3
Gpa1
Kss1
Msg5
Pheromone
Ptp2/Ptp3
Sst2
Ste2
Ste4:Ste18
Ste5
Ste7
Ste11
Ste12
Ste20
Yck

Species not included in model

Bem1
Bni1
Cdc24
Cdc28
Cdc42
Fus1
Hog1
Pbs2
Prm1
Spa2
Ste50
Tec1

Phenomenology

Localization effects

Page Categories

Yeast Pheromone Response Model
Reactions - Yeast Pheromone Response Model
Parameters - Yeast Pheromone Response Model
Species - Yeast Pheromone Response Model