Ste4:Ste18/Ste20 interaction

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Ste4:Ste18 interactions with Ste20

  • Mutational analysis suggests that Ste5 and Ste20 may interact with Ste4 residues on opposite sides of the Ste4/Ste18 coiled-coil. Dowell et al. 1998 PMID 9832519
    • This suggests that Ste5 and Ste20 may be able to simultaneously bind a single Ste4:Ste18.
    • These results are partially confirmed by NMR studies of the interaction between pepetides from Ste20 and Ste4 (Bhattacharjya et al. 2006 PMID 16870141) and additional mutant analysis (Leeuw et al. 1998 PMID 9428767).

Reaction Definition

Assumptions:

Ste4(Gpa1_site, Ste20_site) + Ste20(Ste4_site, Ste11_site) <-> 
   Ste4(Gpa1_site, Ste20_site!1).Ste20(Ste4_site!1, Ste11_site)

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