Yeast pheromone response model

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Contents

Receptor/G protein interactionsSte2RGS(Sst2)/Galpha(Gpa1)/Receptor(Ste2) interactionsSst2Gpa1Ste4Ste18Ste20Ste7Ptp3Msg5Ptp2Ste11/Ste50 interactionsSte11Ste50Fus3Fus3Kss1Kss1Ste5Ste5Dig1/Dig2/Ste12 interactionsDig1Dig2Ste12Ste12 mediated protein synthesisPheromone/Receptor interactionsPheromoneReceptor/G protein interactionsSte2RGS(Sst2)/Galpha(Gpa1)/Receptor(Ste2) interactionsSst2Gpa1Ste18Ste4/Ste5 interactions and Ste5 dimerization/oligomerizationSte4/Ste20 interactionSte4Ste20Ste5/MAPK cascade interactionsSte11/Ste50 interactionsSte50Ste11Ste7Fus3MAPK phosphorylation cascadePtp3Msg5Ste5Fus3Kss1Fus3Kss1Ptp2Dig1/Dig2/Ste12 phosphorylationDig1/Dig2/Ste12 interactionsDig1Dig2Ste12Ste12 mediated protein synthesis

[edit] Reactions

[edit] Receptor/G-Protein

Pheromone/Receptor/G protein interactions

Pheromone/Receptor Interactions
kon_Pheromone_Ste2
koff_Pheromone_Ste2
Receptor/G Protein Interactions
kon_Ste2_Gpa1
koff_Ste2_Gpa1
kon_Ste2_Gpa1Ste4Ste18
koff_Ste2_Gpa1Ste4Ste18
G Protein Association
kon_Gpa1GDP_Ste4Ste18
koff_Gpa1GDP_Ste4Ste18
kon_Gpa1GTP_Ste4Ste18
koff_Gpa1GTP_Ste4Ste18
kon_Ste2Gpa1GDP_Ste4Ste18
koff_Ste2Gpa1GDP_Ste4Ste18
kon_Ste2Gpa1GTP_Ste4Ste18
koff_Ste2Gpa1GTP_Ste4Ste18
Ste2_Gpa1_Ste4Ste18_coop_factor
GTP_modulating_factor

G protein nucleotide hydrolysis/exchange

G Protein Nucleotide Exchange
kcat_Gpa1GDP_GTP
kcat_PheromoneSte2Gpa1GDP_GTP
G Protein Nucleotide Hydrolysis
kcat_Gpa1GTP_GDP
kcat_Sst2Gpa1GTP_GDP

RGS(Sst2)/Galpha(Gpa1)/Receptor(Ste2) interactions

Sst2/Ste2 Interactions
kon_Ste2_Sst2
koff_Ste2_Sst2

Gβ(Ste4)/Gγ(Ste18) interaction

Fus3/Gpa1/Ste4 interactions

[edit] Synthesis/Degradation

Receptor(Ste2) synthesis/endocytosis/degradation

Yck/Ste2 Interactions
kon_Ste2_Yck
koff_Ste2_Yck
kcat_YckSte2_PO4
kcat_YckPheromoneSte2_PO4
Ste2 Degradation
kdeg_Ste2_PO4
Ste2 Synthesis
ksynth_Ste2

RGS(Sst2) synthesis/degradation

Fus3/Sst2 Interactions
kon_MAPKpY_Sst2
koff_MAPKpY_Sst2
kon_MAPKpT_Sst2
koff_MAPKpT_Sst2
kon_MAPKpTpY_Sst2
koff_MAPKpTpY_Sst2
kcat_MAPKpY_Sst2_PO4
kcat_MAPKpT_Sst2_PO4
kcat_MAPKpTpY_Sst2_PO4
Sst2 Degradation
kdeg_Sst2
kdeg_Sst2_PO4
Sst2 Synthesis
ksynth_Sst2

Gα(Gpa1) synthesis/degradation

Gpa1 synthesis/degradation
kdeg_Gpa1
ksynth_Gpa1

[edit] MAPK Cascade

Ste4:Ste18/Ste5 interactions and Ste5 dimerization/oligomerization

Ste5 Dimerization
kon_Ste5_Ste5
koff_Ste5_Ste5
kon_Ste4Ste18Ste5_Ste5
koff_Ste4Ste18Ste5_Ste5
kon_Ste4Ste18Ste5_Ste4Ste18Ste5
koff_Ste4Ste18Ste5_Ste4Ste18Ste5
Ste4Ste18Ste5_Ste5_coop_factor
Ste4Ste18Ste5_Ste4Ste18Ste5_coop_factor
Ste5/Ste4 Interactions
kon_Ste4Ste18_Ste5
koff_Ste4Ste18_Ste5
kon_Ste4Ste18_Ste5Ste5
koff_Ste4Ste18_Ste5Ste5
kon_Ste4Ste18_Ste4Ste18Ste5Ste5
koff_Ste4Ste18_Ste4Ste18Ste5Ste5

Ste4:Ste18/Ste20 interaction

Ste4:Ste18/Ste20 Interactions
kon_Ste4_Ste20
koff_Ste4_Ste20

Ste5/MAPK cascade interactions

Ste5/Ste11 Interactions
kon_Ste5_Ste11
koff_Ste5_Ste11
Ste5/Ste7 Interactions
kon_Ste5_Ste7
koff_Ste5_Ste7
Ste5/Fus3 Interactions
kon_Ste5_Fus3
koff_Ste5_Fus3
Ste5/Kss1 Interactions
kon_Ste5_Kss1
koff_Ste5_Kss1

MAPK phosphorylation cascade

Ste11 Phosphorylation by Ste20
kcat_Ste20Ste4Ste18Ste5Ste11_pS
kcat_Ste20Ste4Ste18Ste5Ste11pS_pS
kcat_Ste20Ste4Ste18Ste5Ste11pSpS_pT
Ste7 Phosphorylation by Ste11
kcat_Ste11pSSte5Ste5Ste7_pS
kcat_Ste11pSSte5Ste5Ste7pS_pT
kcat_Ste11pSpSSte5Ste5Ste7_pS
kcat_Ste11pSpSSte5Ste5Ste7pS_pT
kcat_Ste11pSpSpTSte5Ste5Ste7_pS
kcat_Ste11pSpSpTSte5Ste5Ste7pS_pT
Ste11_pS_only_PO4_factor
Fus3 Phosphorylation by Ste7
kcat_Ste5Ste7pSFus3_pY
kcat_Ste5Ste7pSFus3pY_pT
kcat_Ste5Ste7pSpTFus3_pY
kcat_Ste5Ste7pSpTFus3pY_pT
Ste7_pS_only_PO4_factor
Kss1 Phosphorylation by Ste7
kcat_Ste7pSKss1_pY
kcat_Ste7pSKss1pY_pT
kcat_Ste7pSpTKss1_pY
kcat_Ste7pSpTKss1pY_pT
Ste7_pS_only_PO4_factor

MAPK/phosphatase interactions

Ptp2/Ptp3 Dephosphorylation of MAPKs
kon_Ptp_MAPK
koff_Ptp_MAPK
kcat_Ptp_MAPK_PO4
Msg5 Dephosphorylation of MAPKs
kon_Msg5_MAPK
koff_Msg5_MAPK
kcat_Msg5_MAPK_PO4

Ste7/MAPK interactions

Ste7/MAPK Interactions
kon_Ste7_MAPK
koff_Ste7_MAPK

Ste11/Ste50 interactions

[edit] Synthesis/Degradation

Ste11 synthesis/degradation

Ste11/Fus3 Interactions
kon_MAPKpT_Ste11
koff_MAPKpT_Ste11
kon_MAPKpY_Ste11
koff_MAPKpY_Ste11
kon_MAPKpTpY_Ste11
koff_MAPKpTpY_Ste11
kcat_MAPKpT_Ste11_PO4
kcat_MAPKpY_Ste11_PO4
kcat_MAPKpTpY_Ste11_PO4
Ste11 Degradation
kdeg_Ste11
kdeg_Ste11_PO4
Ste11 Synthesis
ksynth_Ste11

Ste7 synthesis/degradation

Ste7 Degradation
kdeg_Fus3pT_Ste7
Km_deg_Fus3pT_Ste7
kdeg_Fus3pY_Ste7
Km_deg_Fus3pY_Ste7
kdeg_Fus3pTpY_Ste7
Km_deg_Fus3pTpY_Ste7
kdeg_Kss1pT_Ste7
Km_deg_Kss1pT_Ste7
kdeg_Kss1pY_Ste7
Km_deg_Kss1pY_Ste7
kdeg_Kss1pTpY_Ste7
Km_deg_Kss1pTpY_Ste7
Ste7 Synthesis
ksynth_Ste7

[edit] Gene Expression

Dig1/Dig2/Ste12/Tec1 interactions

Dig1/Ste12 Interactions
kon_Ste12_Dig1
koff_Ste12_Dig1
kon_Ste12_Dig1PO4
koff_Ste12_Dig1PO4
kon_Ste12Dig2_Dig1
koff_Ste12Dig2_Dig1
kon_Ste12Dig2_Dig1PO4
koff_Ste12Dig2_Dig1PO4
kon_Ste12Kss1_Dig1
koff_Ste12Kss1_Dig1
kon_Ste12Kss1_Dig1PO4
koff_Ste12Kss1_Dig1PO4
kon_Ste12Kss1Dig2_Dig1
koff_Ste12Kss1Dig2_Dig1
kon_Ste12Kss1Dig2_Dig1PO4
koff_Ste12Kss1Dig2_Dig1PO4
kon_Ste12Fus3_Dig1
koff_Ste12Fus3_Dig1
kon_Ste12Fus3_Dig1PO4
koff_Ste12Fus3_Dig1PO4
kon_Ste12Fus3Dig2_Dig1
koff_Ste12Fus3Dig2_Dig1
kon_Ste12Fus3Dig2_Dig1PO4
koff_Ste12Fus3Dig2_Dig1PO4
Ste12_Dig1_PO4_factor
Ste12_Dig1_Dig2_coop_factor
Ste12_Dig1_Kss1_coop_factor
Ste12_Dig1_Fus3_coop_factor
Dig2/Ste12 Interactions
kon_Ste12_Dig2
kon_Ste12_Dig2PO4
kon_Ste12Dig1_Dig2
kon_Ste12Dig1_Dig2PO4
koff_Ste12_Dig2
koff_Ste12_Dig2PO4
koff_Ste12Dig1_Dig2
koff_Ste12Dig1_Dig2PO4
Ste12_Dig2_PO4_factor
Ste12_Dig1_Dig2_coop_factor
Ste12/Kss1 Interactions
kon_Ste12_Kss1
kon_Ste12_Kss1pT
kon_Ste12_Kss1pY
kon_Ste12_Kss1pTpY
kon_Ste12Dig1_Kss1
kon_Ste12Dig1_Kss1pT
kon_Ste12Dig1_Kss1pY
kon_Ste12Dig1_Kss1pTpY
koff_Ste12_Kss1
koff_Ste12_Kss1pT
koff_Ste12_Kss1pY
koff_Ste12_Kss1pTpY
koff_Ste12Dig1_Kss1
koff_Ste12Dig1_Kss1pT
koff_Ste12Dig1_Kss1pY
koff_Ste12Dig1_Kss1pTpY
Ste12_Kss1_pT_factor
Ste12_Kss1_pY_factor
Ste12_Kss1_pTpY_factor
Ste12_Dig1_Kss1_coop_factor
Ste12/Fus3 Interactions
kon_Ste12_Fus3
kon_Ste12_Fus3pT
kon_Ste12_Fus3pY
kon_Ste12_Fus3pTpY
kon_Ste12Dig1_Fus3
kon_Ste12Dig1_Fus3pT
kon_Ste12Dig1_Fus3pY
kon_Ste12Dig1_Fus3pTpY
koff_Ste12_Fus3
koff_Ste12_Fus3pT
koff_Ste12_Fus3pY
koff_Ste12_Fus3pTpY
koff_Ste12Dig1_Fus3
koff_Ste12Dig1_Fus3pT
koff_Ste12Dig1_Fus3pY
koff_Ste12Dig1_Fus3pTpY
Ste12_Fus3_pT_factor
Ste12_Fus3_pY_factor
Ste12_Fus3_pTpY_factor
Ste12_Dig1_Fus3_coop_factor

Dig1/Dig2/Ste12 phosphorylation

Dig1 Phosphorylation
kon_Fus3pT_Dig1
koff_Fus3pT_Dig1
kon_Fus3pY_Dig1
koff_Fus3pY_Dig1
kon_Fus3pTpY_Dig1
koff_Fus3pTpY_Dig1
kon_Kss1pT_Dig1
koff_Kss1pT_Dig1
kon_Kss1pY_Dig1
koff_Kss1pY_Dig1
kon_Kss1pTpY_Dig1
koff_Kss1pTpY_Dig1
kcat_Fus3pT_Dig1_PO4
kcat_Fus3pY_Dig1_PO4
kcat_Fus3pTpY_Dig1_PO4
kcat_Kss1pT_Dig1_PO4
kcat_Kss1pY_Dig1_PO4
kcat_Kss1pTpY_Dig1_PO4
Dig2 Phosphorylation
kon_Fus3pT_Dig2
koff_Fus3pT_Dig2
kon_Fus3pY_Dig2
koff_Fus3pY_Dig2
kon_Fus3pTpY_Dig2
koff_Fus3pTpY_Dig2
kon_Kss1pT_Dig2
koff_Kss1pT_Dig2
kon_Kss1pY_Dig2
koff_Kss1pY_Dig2
kon_Kss1pTpY_Dig2
koff_Kss1pTpY_Dig2
kcat_Fus3pT_Dig2_PO4
kcat_Fus3pY_Dig2_PO4
kcat_Fus3pTpY_Dig2_PO4
kcat_Kss1pT_Dig2_PO4
kcat_Kss1pY_Dig2_PO4
kcat_Kss1pTpY_Dig2_PO4

Ste12 mediated protein synthesis

Dig2 Synthesis
Ksynth_Ste12_Dig2
Km_synth_Ste12_Dig2
Far1 Synthesis
Ksynth_ Ste12_Far1
Km_synth_Ste12_Far1
Fus3 Synthesis
Ksynth_Ste12_Fus3
Km_synth_Ste12_Fus3
Gpa1 Synthesis
Ksynth_Ste12_Gpa1
Km_synth_Ste12_Gpa1
Msg5 Synthesis
Ksynth_Ste12_Msg5
Km_synth_Ste12_Msg5
Ptp Synthesis
Ksynth_Ste12_Ptp
Km_synth_Ste12_Ptp
Sst2 Synthesis
Ksynth_Ste12_Sst2
Km_synth_Ste12_Sst2
Ste2 Synthesis
Ksynth_Ste12_Ste2
Km_synth_Ste12_Ste2
Ste12 Synthesis
Ksynth_Ste12_Ste12
Km_synth_Ste12_Ste12
[edit] Synthesis/Degradation

Tec1 synthesis/degradation
Ste12 synthesis/degradation

kdeg_Fus3pT_Ste12
Km_deg_Fus3pT_Ste12
kdeg_Fus3pY_Ste12
Km_deg_Fus3pY_Ste12
kdeg_Fus3pTpY_Ste12
Km_deg_Fus3pTpY_Ste12
kdeg_Kss1pT_Ste12
Km_deg_Kss1pT_Ste12
kdeg_Kss1pY_Ste12
Km_deg_Kss1pY_Ste12
kdeg_Kss1pTpY_Ste12
Km_deg_Kss1pTpY_Ste12

[edit] Other

Far1/MAPK interactions

Far1/Fus3 Interactions
Kd_Fus3pTpY_Far1
kon_Fus3pT_Far1
koff_Fus3pT_Far1
kon_Fus3pY_Far1
koff_Fus3pY_Far1
kon_Fus3pTpY_Far1
koff_Fus3pTpY_Far1
kcat_Fus3pT_Far1_PO4
kcat_Fus3pY_Far1_PO4
kcat_Fus3pTpY_Far1_PO4
Far1/Kss1 Interactions
Kd_Kss1pTpY_Far1
kon_Kss1pT_Far1
koff_Kss1pT_Far1
kon_Kss1pY_Far1
koff_Kss1pY_Far1
kon_Kss1pTpY_Far1
koff_Kss1pTpY_Far1
kcat_Kss1pT_Far1_PO4
kcat_Kss1pY_Far1_PO4
kcat_Kss1pTpY_Far1_PO4

Non-specific dephosphorylation

kcat_nonspecific_dephosph

Protein dilution/synthesis due to cell growth

Protein Dilution
kdilution
Protein Synthesis
kdilutionsynth_pheromone
kdilutionsynth_Dig1
kdilutionsynth_Dig2
kdilutionsynth_Far1
kdilutionsynth_Fus3
kdilutionsynth_Gpa1
kdilutionsynth_Kss1
kdilutionsynth_Msg5
kdilutionsynth_Ptp
kdilutionsynth_Sst2
kdilutionsynth_Ste2
kdilutionsynth_Ste4Ste18
kdilutionsynth_Ste5
kdilutionsynth_Ste7
kdilutionsynth_Ste11
kdilutionsynth_Ste12
kdilutionsynth_Ste20
kdilutionsynth_Yck

Cell cycle regulation of pheromone response

Pheromone-dependent cell cycle arrest

[edit] Parameter Constraint Assumption Pages

MAPK/target interaction properties
Gpa1/Ste4 binding and nucleotide hydrolysis/exchange rate constant constraints
Ste2/Gpa1/Ste4:Ste18 binding rate constant constraints
Ste5 dimerization and Ste4 binding rate constant constraints
Dig1/Dig2/Ste12/MAPK binding rate constant constraints

[edit] Elemental Species

Cell
Dig1
Dig2
Far1
Fus3
Gpa1
Kss1
Msg5
Pheromone
Ptp2/Ptp3
Sst2
Ste2
Ste4:Ste18
Ste5
Ste7
Ste11
Ste12
Ste20
Yck

[edit] Species not included in model

Bem1
Bni1
Cdc24
Cdc28
Cdc42
Fus1
Hog1
Pbs2
Prm1
Spa2
Ste50
Tec1

[edit] Phenomenology

Localization effects

[edit] Page Categories

Yeast Pheromone Response Model
Reactions - Yeast Pheromone Response Model
Parameters - Yeast Pheromone Response Model
Species - Yeast Pheromone Response Model

Retrieved from "http://yeastpheromonemodel.org/wiki/Yeast_pheromone_response_model"
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