Yeast pheromone response model

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Contents

Receptor/G protein interactionsSte2RGS(Sst2)/Galpha(Gpa1)/Receptor(Ste2) interactionsSst2Gpa1Ste4Ste18Ste20Ste7Ptp3Msg5Ptp2Ste11/Ste50 interactionsSte11Ste50Fus3Fus3Kss1Kss1Ste5Ste5Dig1/Dig2/Ste12 interactionsDig1Dig2Ste12Ste12 mediated protein synthesisPheromone/Receptor interactionsPheromoneReceptor/G protein interactionsSte2RGS(Sst2)/Galpha(Gpa1)/Receptor(Ste2) interactionsSst2Gpa1Ste18Ste4/Ste5 interactions and Ste5 dimerization/oligomerizationSte4/Ste20 interactionSte4Ste20Ste5/MAPK cascade interactionsSte11/Ste50 interactionsSte50Ste11Ste7Fus3MAPK phosphorylation cascadePtp3Msg5Ste5Fus3Kss1Fus3Kss1Ptp2Dig1/Dig2/Ste12 phosphorylationDig1/Dig2/Ste12 interactionsDig1Dig2Ste12Ste12 mediated protein synthesis

Reactions

Receptor/G-Protein

Pheromone/Receptor/G protein interactions

Pheromone/Receptor Interactions
kon_Pheromone_Ste2
koff_Pheromone_Ste2
Receptor/G Protein Interactions
kon_Ste2_Gpa1
koff_Ste2_Gpa1
kon_Ste2_Gpa1Ste4Ste18
koff_Ste2_Gpa1Ste4Ste18
G Protein Association
kon_Gpa1GDP_Ste4Ste18
koff_Gpa1GDP_Ste4Ste18
kon_Gpa1GTP_Ste4Ste18
koff_Gpa1GTP_Ste4Ste18
kon_Ste2Gpa1GDP_Ste4Ste18
koff_Ste2Gpa1GDP_Ste4Ste18
kon_Ste2Gpa1GTP_Ste4Ste18
koff_Ste2Gpa1GTP_Ste4Ste18
Ste2_Gpa1_Ste4Ste18_coop_factor
GTP_modulating_factor

G protein nucleotide hydrolysis/exchange

G Protein Nucleotide Exchange
kcat_Gpa1GDP_GTP
kcat_PheromoneSte2Gpa1GDP_GTP
G Protein Nucleotide Hydrolysis
kcat_Gpa1GTP_GDP
kcat_Sst2Gpa1GTP_GDP

RGS(Sst2)/Galpha(Gpa1)/Receptor(Ste2) interactions

Sst2/Ste2 Interactions
kon_Ste2_Sst2
koff_Ste2_Sst2

Gβ(Ste4)/Gγ(Ste18) interaction

Fus3/Gpa1/Ste4 interactions

Synthesis/Degradation

Receptor(Ste2) synthesis/endocytosis/degradation

Yck/Ste2 Interactions
kon_Ste2_Yck
koff_Ste2_Yck
kcat_YckSte2_PO4
kcat_YckPheromoneSte2_PO4
Ste2 Degradation
kdeg_Ste2_PO4
Ste2 Synthesis
ksynth_Ste2

RGS(Sst2) synthesis/degradation

Fus3/Sst2 Interactions
kon_MAPKpY_Sst2
koff_MAPKpY_Sst2
kon_MAPKpT_Sst2
koff_MAPKpT_Sst2
kon_MAPKpTpY_Sst2
koff_MAPKpTpY_Sst2
kcat_MAPKpY_Sst2_PO4
kcat_MAPKpT_Sst2_PO4
kcat_MAPKpTpY_Sst2_PO4
Sst2 Degradation
kdeg_Sst2
kdeg_Sst2_PO4
Sst2 Synthesis
ksynth_Sst2

Gα(Gpa1) synthesis/degradation

Gpa1 synthesis/degradation
kdeg_Gpa1
ksynth_Gpa1

MAPK Cascade

Ste4:Ste18/Ste5 interactions and Ste5 dimerization/oligomerization

Ste5 Dimerization
kon_Ste5_Ste5
koff_Ste5_Ste5
kon_Ste4Ste18Ste5_Ste5
koff_Ste4Ste18Ste5_Ste5
kon_Ste4Ste18Ste5_Ste4Ste18Ste5
koff_Ste4Ste18Ste5_Ste4Ste18Ste5
Ste4Ste18Ste5_Ste5_coop_factor
Ste4Ste18Ste5_Ste4Ste18Ste5_coop_factor
Ste5/Ste4 Interactions
kon_Ste4Ste18_Ste5
koff_Ste4Ste18_Ste5
kon_Ste4Ste18_Ste5Ste5
koff_Ste4Ste18_Ste5Ste5
kon_Ste4Ste18_Ste4Ste18Ste5Ste5
koff_Ste4Ste18_Ste4Ste18Ste5Ste5

Ste4:Ste18/Ste20 interaction

Ste4:Ste18/Ste20 Interactions
kon_Ste4_Ste20
koff_Ste4_Ste20

Ste5/MAPK cascade interactions

Ste5/Ste11 Interactions
kon_Ste5_Ste11
koff_Ste5_Ste11
Ste5/Ste7 Interactions
kon_Ste5_Ste7
koff_Ste5_Ste7
Ste5/Fus3 Interactions
kon_Ste5_Fus3
koff_Ste5_Fus3
Ste5/Kss1 Interactions
kon_Ste5_Kss1
koff_Ste5_Kss1

MAPK phosphorylation cascade

Ste11 Phosphorylation by Ste20
kcat_Ste20Ste4Ste18Ste5Ste11_pS
kcat_Ste20Ste4Ste18Ste5Ste11pS_pS
kcat_Ste20Ste4Ste18Ste5Ste11pSpS_pT
Ste7 Phosphorylation by Ste11
kcat_Ste11pSSte5Ste5Ste7_pS
kcat_Ste11pSSte5Ste5Ste7pS_pT
kcat_Ste11pSpSSte5Ste5Ste7_pS
kcat_Ste11pSpSSte5Ste5Ste7pS_pT
kcat_Ste11pSpSpTSte5Ste5Ste7_pS
kcat_Ste11pSpSpTSte5Ste5Ste7pS_pT
Ste11_pS_only_PO4_factor
Fus3 Phosphorylation by Ste7
kcat_Ste5Ste7pSFus3_pY
kcat_Ste5Ste7pSFus3pY_pT
kcat_Ste5Ste7pSpTFus3_pY
kcat_Ste5Ste7pSpTFus3pY_pT
Ste7_pS_only_PO4_factor
Kss1 Phosphorylation by Ste7
kcat_Ste7pSKss1_pY
kcat_Ste7pSKss1pY_pT
kcat_Ste7pSpTKss1_pY
kcat_Ste7pSpTKss1pY_pT
Ste7_pS_only_PO4_factor

MAPK/phosphatase interactions

Ptp2/Ptp3 Dephosphorylation of MAPKs
kon_Ptp_MAPK
koff_Ptp_MAPK
kcat_Ptp_MAPK_PO4
Msg5 Dephosphorylation of MAPKs
kon_Msg5_MAPK
koff_Msg5_MAPK
kcat_Msg5_MAPK_PO4

Ste7/MAPK interactions

Ste7/MAPK Interactions
kon_Ste7_MAPK
koff_Ste7_MAPK

Ste11/Ste50 interactions

Synthesis/Degradation

Ste11 synthesis/degradation

Ste11/Fus3 Interactions
kon_MAPKpT_Ste11
koff_MAPKpT_Ste11
kon_MAPKpY_Ste11
koff_MAPKpY_Ste11
kon_MAPKpTpY_Ste11
koff_MAPKpTpY_Ste11
kcat_MAPKpT_Ste11_PO4
kcat_MAPKpY_Ste11_PO4
kcat_MAPKpTpY_Ste11_PO4
Ste11 Degradation
kdeg_Ste11
kdeg_Ste11_PO4
Ste11 Synthesis
ksynth_Ste11

Ste7 synthesis/degradation

Ste7 Degradation
kdeg_Fus3pT_Ste7
Km_deg_Fus3pT_Ste7
kdeg_Fus3pY_Ste7
Km_deg_Fus3pY_Ste7
kdeg_Fus3pTpY_Ste7
Km_deg_Fus3pTpY_Ste7
kdeg_Kss1pT_Ste7
Km_deg_Kss1pT_Ste7
kdeg_Kss1pY_Ste7
Km_deg_Kss1pY_Ste7
kdeg_Kss1pTpY_Ste7
Km_deg_Kss1pTpY_Ste7
Ste7 Synthesis
ksynth_Ste7

Gene Expression

Dig1/Dig2/Ste12/Tec1 interactions

Dig1/Ste12 Interactions
kon_Ste12_Dig1
koff_Ste12_Dig1
kon_Ste12_Dig1PO4
koff_Ste12_Dig1PO4
kon_Ste12Dig2_Dig1
koff_Ste12Dig2_Dig1
kon_Ste12Dig2_Dig1PO4
koff_Ste12Dig2_Dig1PO4
kon_Ste12Kss1_Dig1
koff_Ste12Kss1_Dig1
kon_Ste12Kss1_Dig1PO4
koff_Ste12Kss1_Dig1PO4
kon_Ste12Kss1Dig2_Dig1
koff_Ste12Kss1Dig2_Dig1
kon_Ste12Kss1Dig2_Dig1PO4
koff_Ste12Kss1Dig2_Dig1PO4
kon_Ste12Fus3_Dig1
koff_Ste12Fus3_Dig1
kon_Ste12Fus3_Dig1PO4
koff_Ste12Fus3_Dig1PO4
kon_Ste12Fus3Dig2_Dig1
koff_Ste12Fus3Dig2_Dig1
kon_Ste12Fus3Dig2_Dig1PO4
koff_Ste12Fus3Dig2_Dig1PO4
Ste12_Dig1_PO4_factor
Ste12_Dig1_Dig2_coop_factor
Ste12_Dig1_Kss1_coop_factor
Ste12_Dig1_Fus3_coop_factor
Dig2/Ste12 Interactions
kon_Ste12_Dig2
kon_Ste12_Dig2PO4
kon_Ste12Dig1_Dig2
kon_Ste12Dig1_Dig2PO4
koff_Ste12_Dig2
koff_Ste12_Dig2PO4
koff_Ste12Dig1_Dig2
koff_Ste12Dig1_Dig2PO4
Ste12_Dig2_PO4_factor
Ste12_Dig1_Dig2_coop_factor
Ste12/Kss1 Interactions
kon_Ste12_Kss1
kon_Ste12_Kss1pT
kon_Ste12_Kss1pY
kon_Ste12_Kss1pTpY
kon_Ste12Dig1_Kss1
kon_Ste12Dig1_Kss1pT
kon_Ste12Dig1_Kss1pY
kon_Ste12Dig1_Kss1pTpY
koff_Ste12_Kss1
koff_Ste12_Kss1pT
koff_Ste12_Kss1pY
koff_Ste12_Kss1pTpY
koff_Ste12Dig1_Kss1
koff_Ste12Dig1_Kss1pT
koff_Ste12Dig1_Kss1pY
koff_Ste12Dig1_Kss1pTpY
Ste12_Kss1_pT_factor
Ste12_Kss1_pY_factor
Ste12_Kss1_pTpY_factor
Ste12_Dig1_Kss1_coop_factor
Ste12/Fus3 Interactions
kon_Ste12_Fus3
kon_Ste12_Fus3pT
kon_Ste12_Fus3pY
kon_Ste12_Fus3pTpY
kon_Ste12Dig1_Fus3
kon_Ste12Dig1_Fus3pT
kon_Ste12Dig1_Fus3pY
kon_Ste12Dig1_Fus3pTpY
koff_Ste12_Fus3
koff_Ste12_Fus3pT
koff_Ste12_Fus3pY
koff_Ste12_Fus3pTpY
koff_Ste12Dig1_Fus3
koff_Ste12Dig1_Fus3pT
koff_Ste12Dig1_Fus3pY
koff_Ste12Dig1_Fus3pTpY
Ste12_Fus3_pT_factor
Ste12_Fus3_pY_factor
Ste12_Fus3_pTpY_factor
Ste12_Dig1_Fus3_coop_factor

Dig1/Dig2/Ste12 phosphorylation

Dig1 Phosphorylation
kon_Fus3pT_Dig1
koff_Fus3pT_Dig1
kon_Fus3pY_Dig1
koff_Fus3pY_Dig1
kon_Fus3pTpY_Dig1
koff_Fus3pTpY_Dig1
kon_Kss1pT_Dig1
koff_Kss1pT_Dig1
kon_Kss1pY_Dig1
koff_Kss1pY_Dig1
kon_Kss1pTpY_Dig1
koff_Kss1pTpY_Dig1
kcat_Fus3pT_Dig1_PO4
kcat_Fus3pY_Dig1_PO4
kcat_Fus3pTpY_Dig1_PO4
kcat_Kss1pT_Dig1_PO4
kcat_Kss1pY_Dig1_PO4
kcat_Kss1pTpY_Dig1_PO4
Dig2 Phosphorylation
kon_Fus3pT_Dig2
koff_Fus3pT_Dig2
kon_Fus3pY_Dig2
koff_Fus3pY_Dig2
kon_Fus3pTpY_Dig2
koff_Fus3pTpY_Dig2
kon_Kss1pT_Dig2
koff_Kss1pT_Dig2
kon_Kss1pY_Dig2
koff_Kss1pY_Dig2
kon_Kss1pTpY_Dig2
koff_Kss1pTpY_Dig2
kcat_Fus3pT_Dig2_PO4
kcat_Fus3pY_Dig2_PO4
kcat_Fus3pTpY_Dig2_PO4
kcat_Kss1pT_Dig2_PO4
kcat_Kss1pY_Dig2_PO4
kcat_Kss1pTpY_Dig2_PO4

Ste12 mediated protein synthesis

Dig2 Synthesis
Ksynth_Ste12_Dig2
Km_synth_Ste12_Dig2
Far1 Synthesis
Ksynth_ Ste12_Far1
Km_synth_Ste12_Far1
Fus3 Synthesis
Ksynth_Ste12_Fus3
Km_synth_Ste12_Fus3
Gpa1 Synthesis
Ksynth_Ste12_Gpa1
Km_synth_Ste12_Gpa1
Msg5 Synthesis
Ksynth_Ste12_Msg5
Km_synth_Ste12_Msg5
Ptp Synthesis
Ksynth_Ste12_Ptp
Km_synth_Ste12_Ptp
Sst2 Synthesis
Ksynth_Ste12_Sst2
Km_synth_Ste12_Sst2
Ste2 Synthesis
Ksynth_Ste12_Ste2
Km_synth_Ste12_Ste2
Ste12 Synthesis
Ksynth_Ste12_Ste12
Km_synth_Ste12_Ste12
Synthesis/Degradation

Tec1 synthesis/degradation
Ste12 synthesis/degradation

kdeg_Fus3pT_Ste12
Km_deg_Fus3pT_Ste12
kdeg_Fus3pY_Ste12
Km_deg_Fus3pY_Ste12
kdeg_Fus3pTpY_Ste12
Km_deg_Fus3pTpY_Ste12
kdeg_Kss1pT_Ste12
Km_deg_Kss1pT_Ste12
kdeg_Kss1pY_Ste12
Km_deg_Kss1pY_Ste12
kdeg_Kss1pTpY_Ste12
Km_deg_Kss1pTpY_Ste12

Other

Far1/MAPK interactions

Far1/Fus3 Interactions
Kd_Fus3pTpY_Far1
kon_Fus3pT_Far1
koff_Fus3pT_Far1
kon_Fus3pY_Far1
koff_Fus3pY_Far1
kon_Fus3pTpY_Far1
koff_Fus3pTpY_Far1
kcat_Fus3pT_Far1_PO4
kcat_Fus3pY_Far1_PO4
kcat_Fus3pTpY_Far1_PO4
Far1/Kss1 Interactions
Kd_Kss1pTpY_Far1
kon_Kss1pT_Far1
koff_Kss1pT_Far1
kon_Kss1pY_Far1
koff_Kss1pY_Far1
kon_Kss1pTpY_Far1
koff_Kss1pTpY_Far1
kcat_Kss1pT_Far1_PO4
kcat_Kss1pY_Far1_PO4
kcat_Kss1pTpY_Far1_PO4

Non-specific dephosphorylation

kcat_nonspecific_dephosph

Protein dilution/synthesis due to cell growth

Protein Dilution
kdilution
Protein Synthesis
kdilutionsynth_pheromone
kdilutionsynth_Dig1
kdilutionsynth_Dig2
kdilutionsynth_Far1
kdilutionsynth_Fus3
kdilutionsynth_Gpa1
kdilutionsynth_Kss1
kdilutionsynth_Msg5
kdilutionsynth_Ptp
kdilutionsynth_Sst2
kdilutionsynth_Ste2
kdilutionsynth_Ste4Ste18
kdilutionsynth_Ste5
kdilutionsynth_Ste7
kdilutionsynth_Ste11
kdilutionsynth_Ste12
kdilutionsynth_Ste20
kdilutionsynth_Yck

Cell cycle regulation of pheromone response

Pheromone-dependent cell cycle arrest

Parameter Constraint Assumption Pages

MAPK/target interaction properties
Ste2/Gpa1/Ste4:Ste18 binding rate constant constraints
Ste5 dimerization and Ste4 binding rate constant constraints
Dig1/Dig2/Ste12/MAPK binding rate constant constraints

Elemental Species

Cell
Dig1
Dig2
Far1
Fus3
Gpa1
Kss1
Msg5
Pheromone
Ptp2/Ptp3
Sst2
Ste2
Ste4:Ste18
Ste5
Ste7
Ste11
Ste12
Ste20
Yck

Species not included in model

Bem1
Bni1
Cdc24
Cdc28
Cdc42
Fus1
Hog1
Pbs2
Prm1
Spa2
Ste50
Tec1

Phenomenology

Localization effects

Page Categories

Yeast Pheromone Response Model
Reactions - Yeast Pheromone Response Model
Parameters - Yeast Pheromone Response Model
Species - Yeast Pheromone Response Model

Retrieved from "http://yeastpheromonemodel.org/wiki/Yeast_pheromone_response_model"
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