Cell cycle regulation of pheromone response

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  • Cln2 (and to a lesser extent Cln1), together with Cdc28, acts to repress pheromone response in a cell cycle dependent manner. Oehlen and Cross. 1994 PMID 7926787
    • Deletion of CLN1 and CLN2 eliminates cell cycle repression of FUS1 expression.
    • Overexpression of CLN1 or CLN2 represses pheromone-dependent FUS1 expression. </