Ptp2/Ptp3

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Contents 1 About Ptp2 2 About Ptp3 3 Reactions 4 Species Representation 4.1 Molecule Type 4.2 Model Seed

[edit] About Ptp2

• Ptp2 contains a putative MAPK-binding sequence at residues 208-220. Metodiev et al. 2002 PMID 12029138
• Ptp2 is nuclear. Mattison et al. 1999 PMID 10523653
• Ptp2 is a protein tyrosine phosphatase. Wurgler-Murphy et al. 1997 PMID 9032256

[edit] About Ptp3

• Ptp3 is cytoplasmic. Mattison et al. 1999 PMID 10523653

• Ptp3 is a protein tyrosine phosphatase. Wurgler-Murphy et al. 1997 PMID 9032256

• Ptp3 is found throughout the cytosol and nucleus, although it is slightly more concentrated in the cytosol. Maeder et al. 2007 PMID 17952059

• Ptp3 levels do not significantly change in response to pheromone. Maeder et al. 2007 PMID 17952059

[edit] Reactions

MAPK/phosphatase interactions
Ste12 mediated protein synthesis
Protein dilution/synthesis due to cell growth

[edit] Species Representation

Since we are not treating the cytoplasm and nucleus as deparate compartments, we will lump Ptp2 and Ptp3 together into one species, Ptp.

[edit] Molecule Type

Ptp(MAPK_site)

[edit] Model Seed

Ptp(MAPK_site) Ptp_tot_conc